Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension
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چکیده
منابع مشابه
Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension.
RATIONALE Pulmonary arterial hypertension (PAH) is a rare progressive disease of the pulmonary vasculature that is characterized by endothelial dysfunction, inflammation, and right ventricular dysfunction. OBJECTIVES The main objective was to determine whether endothelial, inflammatory, and cardiac biomarkers would be associated with the World Health Organization functional assessment and sur...
متن کاملTowards prognostic biomarkers in pulmonary arterial hypertension.
T he most reliable way to assess the clinical impact of a therapeutic intervention in pulmonary arterial hypertension (PAH) is through its effect on well-defined clinical end-points, such as mortality. However, this standard is often impractical because of the long period and large number of patients required to reach these clinical end-points, and substitutes, such as the 6-min walking distanc...
متن کاملThe prognostic significance of inspiratory capacity in pulmonary arterial hypertension.
BACKGROUND Patients with pulmonary arterial hypertension (PAH) present with an altered inspiratory capacity (IC) reflecting dynamic hyperinflation (DH) that leads to mechanical constraints and excessive ventilatory demand, particularly during exercise, resulting in exertional dyspnea. OBJECTIVES Assessment of the long-term consequences of altered IC and DH in PAH. METHODS 50 patients with n...
متن کاملCirculating Biomarkers in Pulmonary Arterial Hypertension
Zeenat Safdar, MD Pulmonary, Critical Care and Sleep Medicine Baylor College of Medicine Houston, TX Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature that leads to exercise limitation, right heart failure, and death. There is a need for biomarkers that can aid in early detection, disease surveillance, and treatment monitoring in PAH. Several potential ...
متن کاملPrognostic value of exercise pulmonary haemodynamics in pulmonary arterial hypertension.
The aim of the study was to investigate the prognostic value of right heart catheterisation variables measured during exercise. 55 incident patients with idiopathic, familial or anorexigen-associated pulmonary arterial hypertension (PAH) underwent right heart catheterisation at rest and during exercise and 6-min walk testing before PAH treatment initiation. Patients were treated according to re...
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ژورنال
عنوان ژورنال: Annals of the American Thoracic Society
سال: 2016
ISSN: 2329-6933,2325-6621
DOI: 10.1513/annalsats.201508-543oc